HtrA2/Omi, a Sheep in Wolf's Clothing
نویسندگان
چکیده
Mammalian mitochondrial HtrA2/Omi was originally described as an apoptosis inducer, but rather than having extra cells, mice with mutant HtrA2/Omi suffer from a neurodegenerative disease due to progressive mitochondrial damage. This suggests that instead of promoting cell death by antagonizing inhibitor of apoptosis (IAP) proteins, the primary function of HtrA2/Omi is to handle misfolded proteins in the mitochondria.
منابع مشابه
A sheep in wolf's clothing.
Most are familiar with the biblical warnings about false prophets presenting as the wolf in sheep's clothing, but in this issue of Blood, Mansoor and colleagues expose a sheep in wolf's clothing by shining a bright light on a newly described benign disease previously pretending to be a very bad malignancy, and doing so quite convincingly.
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ورودعنوان ژورنال:
- Cell
دوره 115 شماره
صفحات -
تاریخ انتشار 2003